Blocking effects of human tau on squid giant synapse transmission and its prevention by T-817 MA

Blocking effects of human tau on squid giant synapse transmission and its prevention by T-817 MA

Filamentous tau inclusions are hallmarks of Alzheimer’s disease (AD) and related neurodegenerative tauopathies, but the molecular mechanisms involved in tau mediated changes in neuronal function and their possible effects on synaptic transmission are unknown. We have evaluated the effects of human t...

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Bibliographic Details
Main Authors: Herman eMoreno, Soonwook eChoi, Eunah eYu, Janaina eBrusco, Jesus eAvila, Jorge eMoreira, Mutsuyuki eSugimori, Rodolfo R Llinas
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-05-01
Series:Frontiers in Synaptic Neuroscience
Subjects:
Synaptic Transmission
Synaptic Vesicles
Tauopathies
neurodegenerative
Altzheimer's disease
human tau
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnsyn.2011.00003/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnsyn.2011.00003/full

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