Inhibition of serine palmitoyltransferase delays the onset of radiation-induced pulmonary fibrosis through the negative regulation of sphingosine kinase-1 expression[S]

Inhibition of serine palmitoyltransferase delays the onset of radiation-induced pulmonary fibrosis through the negative regulation of sphingosine kinase-1 expression[S]

The enforcement of sphingosine-1-phosphate (S1P) signaling network protects from radiation-induced pneumonitis. We now demonstrate that, in contrast to early postirradiation period, late postirradiation sphingosine kinase-1 (SphK1) and sphingoid base-1-phosphates are associated with radiation-induce...

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Bibliographic Details
Main Authors: Irina Gorshkova, Tong Zhou, Biji Mathew, Jeffrey R. Jacobson, Daisuke Takekoshi, Palash Bhattacharya, Brett Smith, Bulent Aydogan, Ralph R. Weichselbaum, Viswanathan Natarajan, Joe G.N. Garcia, Evgeny V. Berdyshev
Format: Article
Language:English
Published: Elsevier 2012-08-01
Series:Journal of Lipid Research
Subjects:
sphingosine-1-phospate
dihydrosphingosine-1-phosphate
myriocin
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520418590

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http://www.sciencedirect.com/science/article/pii/S0022227520418590

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