How to design a dose-finding study using the continual reassessment method

How to design a dose-finding study using the continual reassessment method

Abstract Introduction The continual reassessment method (CRM) is a model-based design for phase I trials, which aims to find the maximum tolerated dose (MTD) of a new therapy. The CRM has been shown to be more accurate in targeting the MTD than traditional rule-based approaches such as the 3 + 3 des...

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Bibliographic Details
Main Authors: Graham M. Wheeler, Adrian P. Mander, Alun Bedding, Kristian Brock, Victoria Cornelius, Andrew P. Grieve, Thomas Jaki, Sharon B. Love, Lang’o Odondi, Christopher J. Weir, Christina Yap, Simon J. Bond
Format: Article
Language:English
Published: BMC 2019-01-01
Series:BMC Medical Research Methodology
Subjects:
Adaptive designs
Continual reassessment method
Dose escalation
Dose-finding
Maximum tolerated dose
Phase I trials
Online Access:http://link.springer.com/article/10.1186/s12874-018-0638-z

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http://link.springer.com/article/10.1186/s12874-018-0638-z

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