Loss of a neural AMP-activated kinase mimics the effects of elevated serotonin on fat, movement, and hormonal secretions.

Loss of a neural AMP-activated kinase mimics the effects of elevated serotonin on fat, movement, and hormonal secretions.

AMP-activated protein kinase (AMPK) is an evolutionarily conserved master regulator of metabolism and a therapeutic target in type 2 diabetes. As an energy sensor, AMPK activity is responsive to both metabolic inputs, for instance the ratio of AMP to ATP, and numerous hormonal cues. As in mammals, e...

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Bibliographic Details
Main Authors: Katherine A Cunningham, Aude D Bouagnon, Alexandre G Barros, Lin Lin, Leandro Malard, Marco Aurélio Romano-Silva, Kaveh Ashrafi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-06-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4055570?pdf=render

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http://europepmc.org/articles/PMC4055570?pdf=render

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