Phosphorylated TDP-43 (pTDP-43) aggregates in the axial skeletal muscle of patients with sporadic and familial amyotrophic lateral sclerosis

Phosphorylated TDP-43 (pTDP-43) aggregates in the axial skeletal muscle of patients with sporadic and familial amyotrophic lateral sclerosis

Abstract Muscle atrophy with weakness is a core feature of amyotrophic lateral sclerosis (ALS) that has long been attributed to motor neuron loss alone. However, several studies in ALS patients, and more so in animal models, have challenged this assumption with the latter providing direct evidence t...

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Bibliographic Details
Main Authors: Matthew D. Cykowski, Suzanne Z. Powell, Joan W. Appel, Anithachristy S. Arumanayagam, Andreana L. Rivera, Stanley H. Appel
Format: Article
Language:English
Published: BMC 2018-04-01
Series:Acta Neuropathologica Communications
Subjects:
Amyotrophic lateral sclerosis
Skeletal muscle
Inclusion body myositis
Paraspinous muscle
p62/ sequestosome-1
Autophagy
Online Access:http://link.springer.com/article/10.1186/s40478-018-0528-y

Internet

http://link.springer.com/article/10.1186/s40478-018-0528-y

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