Downregulation of STAT3, β-Catenin, and Notch-1 by Single and Combinations of siRNA Treatment Enhance Chemosensitivity of Wild Type and Doxorubicin Resistant MCF7 Breast Cancer Cells to Doxorubicin

Downregulation of STAT3, β-Catenin, and Notch-1 by Single and Combinations of siRNA Treatment Enhance Chemosensitivity of Wild Type and Doxorubicin Resistant MCF7 Breast Cancer Cells to Doxorubicin

Combinatorial therapeutic strategies using siRNA and small molecules to eradicate tumors are emerging. Targeting multiple signaling pathways decreases the chances of cancer cells switching and adapting new signaling processes that may occur when using a single therapeutic modality. Aberrant function...

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Bibliographic Details
Main Authors: Walhan Alshaer, Dana A. Alqudah, Suha Wehaibi, Duaa Abuarqoub, Malek Zihlif, Ma’mon M. Hatmal, Abdalla Awidi
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:International Journal of Molecular Sciences
Subjects:
breast cancer
siRNA
Notch-1
STAT3
β-catenin
doxorubicin
drug-resistance
Online Access:https://www.mdpi.com/1422-0067/20/15/3696

Internet

https://www.mdpi.com/1422-0067/20/15/3696

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