Accumulation of 3-hydroxytetradecenoic acid: Cause or corollary of glucolipotoxic impairment of pancreatic β-cell bioenergetics?

Accumulation of 3-hydroxytetradecenoic acid: Cause or corollary of glucolipotoxic impairment of pancreatic β-cell bioenergetics?

Objectives: Hyperglycemia and elevated blood lipids are the presumed precipitating causes of β-cell damage in T2DM as the result of a process termed “glucolipotoxicity”. Here, we tested whether glucolipotoxic pathophysiology is caused by defective bioenergetics using islets in culture. Methods: Insu...

Full description

Bibliographic Details
Main Authors: Nicolai M. Doliba, Qing Liu, Changhong Li, Jie Chen, Pan Chen, Chengyang Liu, David W. Frederick, Joseph A. Baur, Michael J. Bennett, Ali Naji, Franz M. Matschinsky
Format: Article
Language:English
Published: Elsevier 2015-12-01
Series:Molecular Metabolism
Subjects:
Pancreatic islets
Fatty acids
Oxygen consumption
Insulin secretion
Mitochondrial fatty acid oxidation
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877815001805

Internet

http://www.sciencedirect.com/science/article/pii/S2212877815001805

Similar Items