Including random centre effects in design, analysis and presentation of multi-centre trials

Abstract Background In large multicentre trials in diverse settings, there is uncertainty about the need to adjust for centre variation in design and analysis. A key distinction is the difference between variation in outcome (independent of treatment) and variation in treatment effect. Through re-an...

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Bibliographic Details
Main Authors: Kate Edgar, Ian Roberts, Linda Sharples
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Trials
Subjects:
Online Access:https://doi.org/10.1186/s13063-021-05266-w