4C-ker: A Method to Reproducibly Identify Genome-Wide Interactions Captured by 4C-Seq Experiments.

4C-Seq has proven to be a powerful technique to identify genome-wide interactions with a single locus of interest (or "bait") that can be important for gene regulation. However, analysis of 4C-Seq data is complicated by the many biases inherent to the technique. An important consideration...

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Bibliographic Details
Main Authors: Ramya Raviram, Pedro P Rocha, Christian L Müller, Emily R Miraldi, Sana Badri, Yi Fu, Emily Swanzey, Charlotte Proudhon, Valentina Snetkova, Richard Bonneau, Jane A Skok
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-03-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC4777514?pdf=render