An immunotoxin targeting Ebola virus glycoprotein inhibits Ebola virus production from infected cells.

Ebola virus (EBOV), a member of the mononegaviral family Filoviridae, causes severe disease associated with high lethality in humans. Despite enormous progress in development of EBOV medical countermeasures, no anti-EBOV treatment has been approved. We designed an immunotoxin in which a single-chain...

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Bibliographic Details
Main Authors: Yingyun Cai, Shuiqing Yu, Xiaoli Chi, Sheli R Radoshitzky, Jens H Kuhn, Edward A Berger
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0245024