Down-regulation of E-cadherin enhances prostate cancer chemoresistance via Notch signaling

Down-regulation of E-cadherin enhances prostate cancer chemoresistance via Notch signaling

Abstract Background The chemoresistance of prostate cancer (PCa) is invariably associated with the aggressiveness and metastasis of this disease. New emerging evidence indicates that the epithelial-to-mesenchymal transition (EMT) may play pivotal roles in the development of chemoresistance and metas...

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Bibliographic Details
Main Authors: Wenchu Wang, Lihui Wang, Atsushi Mizokami, Junlin Shi, Chunlin Zou, Jinlu Dai, Evan T. Keller, Yi Lu, Jian Zhang
Format: Article
Language:English
Published: BMC 2017-03-01
Series:Chinese Journal of Cancer
Subjects:
Epithelial-to-mesenchymal transition
E-cadherin
Chemoresistance
Notch signaling
Prostate cancer
Online Access:http://link.springer.com/article/10.1186/s40880-017-0203-x

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