Differential Expression of Insulin-Like Growth Factor 1 and Wnt Family Member 4 Correlates With Functional Heterogeneity of Human Dermal Fibroblasts

Differential Expression of Insulin-Like Growth Factor 1 and Wnt Family Member 4 Correlates With Functional Heterogeneity of Human Dermal Fibroblasts

Although human dermis contains distinct fibroblast subpopulations, the functional heterogeneity of fibroblast lines from different donors is under-appreciated. We identified one commercially sourced fibroblast line (c64a) that failed to express α-smooth muscle actin (α-SMA), a marker linked to fibro...

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Bibliographic Details
Main Authors: Oliver J. Culley, Blaise Louis, Christina Philippeos, Bénédicte Oulès, Matthieu Tihy, Joe M. Segal, Della Hyliands, Gail Jenkins, Ranjit K. Bhogal, Richard C. Siow, Fiona M. Watt
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
skin
fibroblasts
signalling
epidermis
cell culture
IGF1
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.628039/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.628039/full

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