Anti-GBM glomerulonephritis involves IL-1 but is independent of NLRP3/ASC inflammasome-mediated activation of caspase-1.

Anti-GBM glomerulonephritis involves IL-1 but is independent of NLRP3/ASC inflammasome-mediated activation of caspase-1.

IL-1β and IL-18 are proinflammatory cytokines that contribute to renal immune complex disease, but whether IL-1β and IL-18 are mediators of intrinsic glomerular inflammation is unknown. In contrast to other cytokines the secretion of IL-1β and IL-18 requires a second stimulus that activates the infl...

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Bibliographic Details
Main Authors: Julia Lichtnekert, Onkar P Kulkarni, Shrikant R Mulay, Khader Valli Rupanagudi, Mi Ryu, Ramanjaneyulu Allam, Volker Vielhauer, Dan Muruve, Maja T Lindenmeyer, Clemens D Cohen, Hans-Joachim Anders
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3203143?pdf=render

Internet

http://europepmc.org/articles/PMC3203143?pdf=render

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