A MicroRNA Network Controls Legionella pneumophila Replication in Human Macrophages via LGALS8 and MX1

A MicroRNA Network Controls Legionella pneumophila Replication in Human Macrophages via LGALS8 and MX1

Cases of Legionella pneumophila pneumonia occur worldwide, with potentially fatal outcome. When causing human disease, Legionella injects a plethora of virulence factors to reprogram macrophages to circumvent immune defense and create a replication niche. By analyzing Legionella-induced changes in m...

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Bibliographic Details
Main Authors: Christina E. Herkt, Brian E. Caffrey, Kristin Surmann, Sascha Blankenburg, Manuela Gesell Salazar, Anna L. Jung, Stefanie M. Herbel, Kerstin Hoffmann, Leon N. Schulte, Wei Chen, Alexandra Sittka-Stark, Uwe Völker, Martin Vingron, Annalisa Marsico, Wilhelm Bertrams, Bernd Schmeck
Format: Article
Language:English
Published: American Society for Microbiology 2020-03-01
Series:mBio
Subjects:
mirna
infection
macrophage
mx1
bacteria
galectin-8
legionella pneumophila
tp53
rig-i
ddx58
infectious disease
inflammation
macrophages
microrna
Online Access:https://doi.org/10.1128/mBio.03155-19

Internet

https://doi.org/10.1128/mBio.03155-19

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