Improved efficacy and reduced toxicity of doxorubicin encapsulated in sulfatide-containing nanoliposome in a glioma model.

Improved efficacy and reduced toxicity of doxorubicin encapsulated in sulfatide-containing nanoliposome in a glioma model.

As a glycosphingolipid that can bind to several extracellular matrix proteins, sulfatide has the potential to become an effective targeting agent for tumors overexpressing tenasin-C in their microenvironment. To overcome the dose-limiting toxicity of doxorubicin (DOX), a sulfatide-containing nanolip...

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Bibliographic Details
Main Authors: Jia Lin, Sarah Shigdar, Ding Zhi Fang, Dognxi Xiang, Ming Q Wei, Andrew Danks, Lingxue Kong, Lianghong Li, Liang Qiao, Wei Duan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4114873?pdf=render

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http://europepmc.org/articles/PMC4114873?pdf=render

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