Improved efficacy and reduced toxicity of doxorubicin encapsulated in sulfatide-containing nanoliposome in a glioma model.
As a glycosphingolipid that can bind to several extracellular matrix proteins, sulfatide has the potential to become an effective targeting agent for tumors overexpressing tenasin-C in their microenvironment. To overcome the dose-limiting toxicity of doxorubicin (DOX), a sulfatide-containing nanolip...
Main Authors: | Jia Lin, Sarah Shigdar, Ding Zhi Fang, Dognxi Xiang, Ming Q Wei, Andrew Danks, Lingxue Kong, Lianghong Li, Liang Qiao, Wei Duan |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2014-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC4114873?pdf=render |
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