Missense mutation of VKORC1 leads to medial arterial calcification in rats

Missense mutation of VKORC1 leads to medial arterial calcification in rats

Abstract Vitamin K plays a crucial role in the regulation of vascular calcifications by allowing activation of matrix Gla protein. The dietary requirement for vitamin K is low because of an efficient recycling of vitamin K by vitamin K epoxide reductase (VKORC1). However, decreased VKORC1 activity m...

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Bibliographic Details
Main Authors: Arnaud Michaux, Benjamin Matagrin, Jean-Valéry Debaux, Leon J. Schurgers, Etienne Benoit, Virginie Lattard
Format: Article
Language:English
Published: Nature Publishing Group 2018-09-01
Series:Scientific Reports
Subjects:
Medial Arterial Calcification
Vascular Calcification
Anticoagulant Resistance
Matrix Gla Protein (MGP)
Limited Uptake
Online Access:https://doi.org/10.1038/s41598-018-31788-6

Internet

https://doi.org/10.1038/s41598-018-31788-6

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