High-level expression, purification and characterization of a constitutively active thromboxane A2 receptor polymorphic variant.

High-level expression, purification and characterization of a constitutively active thromboxane A2 receptor polymorphic variant.

G protein-coupled receptors (GPCRs) exhibit some level of basal signaling even in the absence of a bound agonist. This basal or constitutive signaling can have important pathophysiological roles. In the past few years, a number of high resolution crystal structures of GPCRs have been reported, inclu...

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Bibliographic Details
Main Authors: Bing Xu, Raja Chakraborty, Markus Eilers, Shyamala Dakshinamurti, Joe D O'Neil, Steven O Smith, Rajinder P Bhullar, Prashen Chelikani
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3781061?pdf=render

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http://europepmc.org/articles/PMC3781061?pdf=render

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