Nuclear AURKA acquires kinase-independent transactivating function to enhance breast cancer stem cell phenotype

Nuclear AURKA acquires kinase-independent transactivating function to enhance breast cancer stem cell phenotype

Aurora kinase A is a mitotic kinase that facilitates G2/M events. Here the authors show that in breast cancer cells Aurora kinase A has a kinase-independent function in the nucleus by activating the MYC promoter in cooperation with hnRNP K, enhancing the breast cancer stem cell phenotype.

Bibliographic Details
Main Authors: Feimeng Zheng, Caifeng Yue, Guohui Li, Bin He, Wei Cheng, Xi Wang, Min Yan, Zijie Long, Wanshou Qiu, Zhongyu Yuan, Jie Xu, Bing Liu, Qian Shi, Eric W.-F. Lam, Mien-Chie Hung, Quentin Liu
Format: Article
Language:English
Published: Nature Publishing Group 2016-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms10180

Internet

https://doi.org/10.1038/ncomms10180

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