Ganglioside embedded in reconstituted lipoprotein binds cholera toxin with elevated affinity[S]

The ability to exogenously present cell-surface receptors in high-affinity conformations in a synthetic system offers an opportunity to provide host cells with protection from pathogenic toxins. This strategy requires improvement of the synthetic receptor binding affinity against its native counterp...

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Bibliographic Details
Main Authors: Daniel A. Bricarello, Emily J. Mills, Jitka Petrlova, John C. Voss, Atul N. Parikh
Format: Article
Language:English
Published: Elsevier 2010-09-01
Series:Journal of Lipid Research
Subjects:
GM1
Online Access:http://www.sciencedirect.com/science/article/pii/S002222752042303X