"Negative vaccination" by specific CD4 T cell tolerisation enhances virus-specific protective antibody responses.
BACKGROUND: Cooperation of CD4+ T helper cells with specific B cells is crucial for protective vaccination against pathogens by inducing long-lived neutralizing antibody responses. During infection with persistence-prone viruses, prolonged virus replication correlates with low neutralizing antibody...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2007-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC2048666?pdf=render |