Optimising trial designs to identify appropriate antibiotic treatment durations

Optimising trial designs to identify appropriate antibiotic treatment durations

Abstract Background For many infectious conditions, the optimal antibiotic course length remains unclear. The estimation of course length must consider the important trade-off between maximising short- and long-term efficacy and minimising antibiotic resistance and toxicity. Main body Evidence on op...

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Bibliographic Details
Main Authors: Koen B. Pouwels, Mo Yin, Christopher C. Butler, Ben S. Cooper, Sarah Wordsworth, A. Sarah Walker, Julie V. Robotham
Format: Article
Language:English
Published: BMC 2019-06-01
Series:BMC Medicine
Subjects:
Antimicrobial resistance
Design
Randomised trial
Duration of therapy
Antibiotics
Bayesian
Online Access:http://link.springer.com/article/10.1186/s12916-019-1348-z

Internet

http://link.springer.com/article/10.1186/s12916-019-1348-z

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