Transcriptome analysis of human monocytic cells infected with Burkholderia species and exploration of pentraxin-3 as part of the innate immune response against the organisms

Transcriptome analysis of human monocytic cells infected with Burkholderia species and exploration of pentraxin-3 as part of the innate immune response against the organisms

Abstract Background Burkholderia mallei (Bm) is a facultative intracellular bacterial pathogen causing highly-fatal glanders in solipeds and humans. The ability of Bm to thrive intracellularly is thought to be related to exploitation of host immune response-related genes and pathways. Relatively lit...

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Bibliographic Details
Main Authors: Sophie A. Aschenbroich, Eric R. Lafontaine, Maria Cecilia Lopez, Henry V. Baker, Robert J. Hogan
Format: Article
Language:English
Published: BMC 2019-09-01
Series:BMC Medical Genomics
Subjects:
Burkholderia mallei
Burkholderia thailandensis
Transcriptome
Human monocytes
PTX3
Pattern recognition receptor
Online Access:http://link.springer.com/article/10.1186/s12920-019-0575-7

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http://link.springer.com/article/10.1186/s12920-019-0575-7

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