Abrogation of Endogenous Glycolipid Antigen Presentation on Myelin-Laden Macrophages by D-Sphingosine Ameliorates the Pathogenesis of Experimental Autoimmune Encephalomyelitis

Abrogation of Endogenous Glycolipid Antigen Presentation on Myelin-Laden Macrophages by D-Sphingosine Ameliorates the Pathogenesis of Experimental Autoimmune Encephalomyelitis

Background: Although myelin is composed of mostly lipids, the pathological role of myelin lipids in demyelinating diseases remains elusive. The principal lipid of the myelin sheath is β-galactosylceramide (β-Galcer). Its α-anomer (α-Galcer) has been demonstrated to be antigenically presented by macr...

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Bibliographic Details
Main Authors: Yi Ban, Wenjuan Dong, Lixing Zhang, Tian Zhou, Ahmad S. Altiti, Khaleel Ali, David R. Mootoo, Victoria A. Blaho, Timothy Hla, Yi Ren, Xiaojing Ma
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Immunology
Subjects:
endogenous myelin-derived galcer
antigen presentation
IL-17
EAE progression
D-sphingosine
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00404/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00404/full

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