Impact of Mammalian Two-Pore Channel Inhibitors on Long-Distance Electrical Signals in the Characean Macroalga <i>Nitellopsis obtusa </i>and the Early Terrestrial Liverwort <i>Marchantia polymorpha</i>

Impact of Mammalian Two-Pore Channel Inhibitors on Long-Distance Electrical Signals in the Characean Macroalga <i>Nitellopsis obtusa </i>and the Early Terrestrial Liverwort <i>Marchantia polymorpha</i>

Inhibitors of human two-pore channels (TPC1 and TPC2), i.e., verapamil, tetrandrine, and NED-19, are promising medicines used in treatment of serious diseases. In the present study, the impact of these substances on action potentials (APs) and vacuolar channel activity was examined in the aquatic ch...

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Bibliographic Details
Main Authors: Mateusz Koselski, Vilmantas Pupkis, Kenji Hashimoto, Indre Lapeikaite, Agnieszka Hanaka, Piotr Wasko, Egle Plukaite, Kazuyuki Kuchitsu, Vilma Kisnieriene, Kazimierz Trebacz
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Plants
Subjects:
plant action potential
SV/TPC channels
verapamil
tetrandrine
NED-19
Online Access:https://www.mdpi.com/2223-7747/10/4/647

Internet

https://www.mdpi.com/2223-7747/10/4/647

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