Synthetic DNA delivery by electroporation promotes robust in vivo sulfation of broadly neutralizing anti-HIV immunoadhesin eCD4-IgResearch in context

Synthetic DNA delivery by electroporation promotes robust in vivo sulfation of broadly neutralizing anti-HIV immunoadhesin eCD4-IgResearch in context

Background: Despite vigorous and ongoing efforts, active immunizations have yet to induce broadly neutralizing antibodies (bNAbs) against HIV-1. An alternative approach is to achieve prophylaxis with long-term expression of potent biologic HIV-1 inhibitors with Adeno-associated Virus (AAV), which co...

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Bibliographic Details
Main Authors: Ziyang Xu, Megan C. Wise, Hyeree Choi, Alfredo Perales-Puchalt, Ami Patel, Edgar Tello-Ruiz, Jacqueline D. Chu, Kar Muthumani, David B. Weiner
Format: Article
Language:English
Published: Elsevier 2018-09-01
Series:EBioMedicine
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396418303128

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http://www.sciencedirect.com/science/article/pii/S2352396418303128

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