Adipocyte mTORC1 deficiency promotes adipose tissue inflammation and NLRP3 inflammasome activation via oxidative stress and de novo ceramide synthesis[S]

Adipocyte mTORC1 deficiency promotes adipose tissue inflammation and NLRP3 inflammasome activation via oxidative stress and de novo ceramide synthesis[S]

Mechanistic target of rapamycin complex (mTORC)1 activity is increased in adipose tissue of obese insulin-resistant mice, but its role in the regulation of tissue inflammation is unknown. Herein, we investigated the effects of adipocyte mTORC1 deficiency on adipose tissue inflammation and glucose ho...

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Bibliographic Details
Main Authors: Patricia Chimin, Maynara L. Andrade, Thiago Belchior, Vivian A. Paschoal, Juliana Magdalon, Alex S. Yamashita, Érique Castro, Angela Castoldi, Adriano B. Chaves-Filho, Marcos Y. Yoshinaga, Sayuri Miyamoto, Niels O. Câmara, William T. Festuccia
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Journal of Lipid Research
Subjects:
mechanistic target of rapamycin complex 1
nucleotide oligomerization domain-like receptor pyrin domain-containing 3
insulin resistance
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520339511

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http://www.sciencedirect.com/science/article/pii/S0022227520339511

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