Mesenchymal stromal cell therapy reduces lung inflammation and vascular remodeling and improves hemodynamics in experimental pulmonary arterial hypertension

Mesenchymal stromal cell therapy reduces lung inflammation and vascular remodeling and improves hemodynamics in experimental pulmonary arterial hypertension

Abstract Background Experimental research has reported beneficial effects of mesenchymal stromal cell (MSC) therapy in pulmonary arterial hypertension (PAH). However, these studies either were based on prophylactic protocols or assessed basic remodeling features without evaluating possible mechanism...

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Bibliographic Details
Main Authors: Lucas de Mendonça, Nathane S. Felix, Natália G. Blanco, Jaqueline S. Da Silva, Tatiana P. Ferreira, Soraia C. Abreu, Fernanda F. Cruz, Nazareth Rocha, Patrícia M. Silva, Vanessa Martins, Vera L. Capelozzi, Gizele Zapata-Sudo, Patricia R. M. Rocco, Pedro L. Silva
Format: Article
Language:English
Published: BMC 2017-10-01
Series:Stem Cell Research & Therapy
Subjects:
Pulmonary arterial hypertension
Mesenchymal stromal cells
Hemodynamics
Lung vascular remodeling
Macrophage phenotype
Online Access:http://link.springer.com/article/10.1186/s13287-017-0669-0

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http://link.springer.com/article/10.1186/s13287-017-0669-0

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