Human papillomavirus (HPV) downregulates the expression of IFITM1 and RIPK3 to escape from IFNγ and TNFα-mediated anti-proliferative effects and necroptosis

Human papillomavirus (HPV) downregulates the expression of IFITM1 and RIPK3 to escape from IFNγ and TNFα-mediated anti-proliferative effects and necroptosis

The clearance of a high-risk human papillomavirus (hrHPV) infection takes time and requires the local presence of a strong type 1 cytokine T cell response, suggesting that hrHPV has evolved mechanisms to resist this immune attack. Using an unique system for non, newly and persistent hrHPV infection,...

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Bibliographic Details
Main Authors: Wenbo Ma, Bart Tummers, Edith M.G. van Esch, Renske Goedemans, Cornelis J.M. Melief, Craig Meyers, Judith M. Boer, Sjoerd H Van Der Burg
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-11-01
Series:Frontiers in Immunology
Subjects:
Infection
HPV
immune escape
necroptosis
Th1 cytokines
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00496/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00496/full

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