The heterogeneous human memory CCR6+ T helper-17 populations differ in T-bet and cytokine expression but all activate synovial fibroblasts in an IFNγ-independent manner

The heterogeneous human memory CCR6+ T helper-17 populations differ in T-bet and cytokine expression but all activate synovial fibroblasts in an IFNγ-independent manner

Abstract Background Chronic synovial inflammation is an important hallmark of inflammatory arthritis, but the cells and mechanisms involved are incompletely understood. Previously, we have shown that CCR6+ memory T-helper (memTh) cells and synovial fibroblasts (SF) activate each other in a pro-infla...

Full description

Bibliographic Details
Main Authors: Wendy Dankers, Hannah den Braanker, Sandra M. J. Paulissen, Jan Piet van Hamburg, Nadine Davelaar, Edgar M. Colin, Erik Lubberts
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Arthritis Research & Therapy
Subjects:
Inflammatory arthritis
Cytokines
T cells
Th17
Th17.1
Vitamin D
Online Access:https://doi.org/10.1186/s13075-021-02532-9

Internet

https://doi.org/10.1186/s13075-021-02532-9

Similar Items