Amyloid-precursor-protein-lowering small molecules for disease modifying therapy of Alzheimer's disease.

Amyloid-precursor-protein-lowering small molecules for disease modifying therapy of Alzheimer's disease.

Alzheimer's disease (AD) is the most common form of dementia in the elderly with progressive cognitive decline and memory loss. According to the amyloid-hypothesis, AD is caused by generation and subsequent cerebral deposition of β-amyloid (Aβ). Aβ is generated through sequential cleavage of th...

Full description

Bibliographic Details
Main Authors: Sina Cathérine Rosenkranz, Markus Geissen, Kristina Härter, Beata Szalay, Isidro Ferrer, Jana Vogel, Stephen Smith, Markus Glatzel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3867334?pdf=render

Internet

http://europepmc.org/articles/PMC3867334?pdf=render

Similar Items