In silico identification and experimental validation of hits active against KPC-2 β-lactamase.

In silico identification and experimental validation of hits active against KPC-2 β-lactamase.

Bacterial resistance has become a worldwide concern, particularly after the emergence of resistant strains overproducing carbapenemases. Among these, the KPC-2 carbapenemase represents a significant clinical challenge, being characterized by a broad substrate spectrum that includes aminothiazoleoxim...

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Bibliographic Details
Main Authors: Raphael Klein, Pasquale Linciano, Giuseppe Celenza, Pierangelo Bellio, Sofia Papaioannou, Jesus Blazquez, Laura Cendron, Ruth Brenk, Donatella Tondi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0203241

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https://doi.org/10.1371/journal.pone.0203241

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