Glucagon-like peptide-1 excites firing and increases GABAergic miniature postsynaptic currents (mPSCs) in gonadotropin-releasing hormone (GnRH) neurons of the male mice via activation of nitric oxide (NO) and suppression of endocannabinoid signaling pathways

Glucagon-like peptide-1 excites firing and increases GABAergic miniature postsynaptic currents (mPSCs) in gonadotropin-releasing hormone (GnRH) neurons of the male mice via activation of nitric oxide (NO) and suppression of endocannabinoid signaling pathways

Glucagon-like peptide-1 (GLP-1), a metabolic signal molecule, regulates reproduction, although, the involved molecular mechanisms have not been elucidated, yet. Therefore, responsiveness of gonadotropin-releasing hormone (GnRH) neurons to the GLP-1 analog Exendin-4 and elucidation of molecular pathw...

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Bibliographic Details
Main Authors: Imre Farkas, Csaba Vastagh, Erzsébet Farkas, Flóra Bálint, Katalin Skrapits, Erik Hrabovszky, Csaba Fekete, Zsolt Liposits
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-09-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Nitric Oxide
GABA
TRPV1
anandamide
CB1
endocannabinoid
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2016.00214/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2016.00214/full

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