Binding of HIV-1 gp120 to DC-SIGN promotes ASK-1-dependent activation-induced apoptosis of human dendritic cells.

Binding of HIV-1 gp120 to DC-SIGN promotes ASK-1-dependent activation-induced apoptosis of human dendritic cells.

During disease progression to AIDS, HIV-1 infected individuals become increasingly immunosuppressed and susceptible to opportunistic infections. It has also been demonstrated that multiple subsets of dendritic cells (DC), including DC-SIGN⁺ cells, become significantly depleted in the blood and lymph...

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Bibliographic Details
Main Authors: Yongxiong Chen, Shiuh-Lin Hwang, Vera S F Chan, Nancy P Y Chung, Shu-Rong Wang, Zhongye Li, Jing Ma, Chia-Wei Lin, Ya-Ju Hsieh, Kao-Ping Chang, Sui-Sum Kung, Yi-Chia Wu, Cheng-Wei Chu, Hsiao-Ting Tai, George F Gao, Bojian Zheng, Kazunari K Yokoyama, Jonathan M Austyn, Chen-Lung S Lin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3561151?pdf=render

Internet

http://europepmc.org/articles/PMC3561151?pdf=render

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