The systemic activin response to pancreatic cancer: implications for effective cancer cachexia therapy

The systemic activin response to pancreatic cancer: implications for effective cancer cachexia therapy

Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is a particularly lethal malignancy partly due to frequent, severe cachexia. Serum activin correlates with cachexia and mortality, while exogenous activin causes cachexia in mice. Methods Isoform‐specific activin expression and activities w...

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Bibliographic Details
Main Authors: Xiaoling Zhong, Marianne Pons, Christophe Poirier, Yanlin Jiang, Jianguo Liu, George E. Sandusky, Safi Shahda, Attila Nakeeb, C. Max Schmidt, Michael G. House, Eugene P. Ceppa, Nicholas J. Zyromski, Yunlong Liu, Guanglong Jiang, Marion E. Couch, Leonidas G. Koniaris, Teresa A. Zimmers
Format: Article
Language:English
Published: Wiley 2019-10-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
Pancreatic cancer
Cachexia
Activins
Activin receptor type IIb
Weight loss
Online Access:https://doi.org/10.1002/jcsm.12461

Internet

https://doi.org/10.1002/jcsm.12461

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