Inhibitory effects of oxymatrine on hepatic stellate cells activation through TGF-β/miR-195/Smad signaling pathway

Inhibitory effects of oxymatrine on hepatic stellate cells activation through TGF-β/miR-195/Smad signaling pathway

Abstract Background Oxymatrine (OM), a quinolizidine alkaloid extracted from a herb Sophorae Flavescentis Radix, has been used to treat liver fibrotic diseases. However, the mechanism of its anti-fibrosis effects is still unclear. TGF-β/Smad signaling and miR-195 have been proved to paly an importan...

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Bibliographic Details
Main Authors: Li-Ying Song, Yu-Tao Ma, Wei-Jin Fang, Yang He, Jia-Li Wu, Shan-Ru Zuo, Zhen-Zhen Deng, Sheng-Feng Wang, Shi-Kun Liu
Format: Article
Language:English
Published: BMC 2019-06-01
Series:BMC Complementary and Alternative Medicine
Subjects:
Oxymatrine
miR-195
Smad7
Antifibrogenic effect
HSC-T6
Online Access:http://link.springer.com/article/10.1186/s12906-019-2560-2

Internet

http://link.springer.com/article/10.1186/s12906-019-2560-2

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