Secreted Phosphoprotein 1 Expression in Retinal Mononuclear Phagocytes Links Murine to Human Choroidal Neovascularization

Secreted Phosphoprotein 1 Expression in Retinal Mononuclear Phagocytes Links Murine to Human Choroidal Neovascularization

Age-related macular degeneration (AMD) represents the most common cause of blindness in the elderly in the Western world. An impairment of the outer blood-retina barrier and a localized inflammatory microenvironment cause sprouting of choroidal neovascular membranes (CNV) in neovascular AMD that are...

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Bibliographic Details
Main Authors: Anja Schlecht, Peipei Zhang, Julian Wolf, Adrian Thien, Dennis-Dominik Rosmus, Stefaniya Boneva, Günther Schlunck, Clemens Lange, Peter Wieghofer
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
AMD
CNV
Osteopontin
OPN
SPP1
microglia
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2020.618598/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2020.618598/full

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