Losartan Inhibits SARS-CoV-2 Replication in Vitro

Purpose: SARS-CoV-2 infection is associated with substantial mortality and high morbidity. This study tested the effect of angiotensin II type I receptor blocker, losartan, on SARS-CoV-2 replication and inhibition of the papain-like protease of the virus. Methods: The dose-dependent inhibitory effe...

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Bibliographic Details
Main Authors: Reza Nejat, Ahmad Shahir Sadr, Branden Freitas, Jackelyn Crabttree, Scott D. Pegan, Ralph A. Tripp, David Najafi
Format: Article
Language:English
Published: Canadian Society for Pharmaceutical Sciences 2021-07-01
Series:Journal of Pharmacy & Pharmaceutical Sciences
Online Access:https://journals.library.ualberta.ca/jpps/index.php/JPPS/article/view/31931