Coix Seed Extract Enhances the Anti-Pancreatic Cancer Efficacy of Gemcitabine through Regulating ABCB1- and ABCG2-Mediated Drug Efflux: A Bioluminescent Pharmacokinetic and Pharmacodynamic Study

Coix Seed Extract Enhances the Anti-Pancreatic Cancer Efficacy of Gemcitabine through Regulating ABCB1- and ABCG2-Mediated Drug Efflux: A Bioluminescent Pharmacokinetic and Pharmacodynamic Study

A deep insight into the function and kinetics of ATP-binding cassette (ABC) transporters may aid in the development of pharmaceutics that can minimize the particular facet of chemo-resistance. We utilized bioluminescence imaging to monitor the ABC transporter mediated intracellular drug efflux funct...

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Bibliographic Details
Main Authors: Yifan Qian, Yang Xiong, Di Feng, Yali Wu, Xu Zhang, Liping Chen, Mancang Gu
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:International Journal of Molecular Sciences
Subjects:
coix seed extract
atp-binding cassette (abc) transporters
gemcitabine
bioluminescent pharmacokinetic profile
d-luciferin potassium salt
pancreatic cancer
Online Access:https://www.mdpi.com/1422-0067/20/21/5250

Internet

https://www.mdpi.com/1422-0067/20/21/5250

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