Variable expression of Cre recombinase transgenes precludes reliable prediction of tissue-specific gene disruption by tail-biopsy genotyping.

Variable expression of Cre recombinase transgenes precludes reliable prediction of tissue-specific gene disruption by tail-biopsy genotyping.

The Cre/loxP-system has become the system of choice for the generation of conditional so-called knockout mouse strains, i.e. the tissue-specific disruption of expression of a certain target gene. We here report the loss of expression of Cre recombinase in a transgenic mouse strain with increasing nu...

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Bibliographic Details
Main Authors: Tim J Schulz, Markus Glaubitz, Doreen Kuhlow, René Thierbach, Marc Birringer, Pablo Steinberg, Andreas F H Pfeiffer, Michael Ristow
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC1995755?pdf=render

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http://europepmc.org/articles/PMC1995755?pdf=render

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