A subset of mobilized human hematopoietic stem cells express germ layer lineage genes which can be modulated by culture conditions

A subset of mobilized human hematopoietic stem cells express germ layer lineage genes which can be modulated by culture conditions

Abstract Background Adult bone marrow contains stem cells that replenish the myeloid and lymphoid lineages. A subset of human and mouse CD34+ bone marrow stem cells can be propagated in culture to autonomously express embryonic stem cell genes and embryonic germ layer lineage genes. The current stud...

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Bibliographic Details
Main Authors: Tapas Makar, Vamshi K. Nimmagadda, Poornachander R. Guda, Brian Hampton, Weiliang Huang, Maureen A. Kane, Paul S. Fishman, Bernard Pessac, Christopher T. Bever, David Trisler
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Stem Cell Research & Therapy
Subjects:
CD34+ stem cells
Human bone marrow stem cell
ESC genes
Lineage genes
Pancreas
Insulin
Online Access:http://link.springer.com/article/10.1186/s13287-018-0858-5

Internet

http://link.springer.com/article/10.1186/s13287-018-0858-5

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