A subset of mobilized human hematopoietic stem cells express germ layer lineage genes which can be modulated by culture conditions
Abstract Background Adult bone marrow contains stem cells that replenish the myeloid and lymphoid lineages. A subset of human and mouse CD34+ bone marrow stem cells can be propagated in culture to autonomously express embryonic stem cell genes and embryonic germ layer lineage genes. The current stud...
Main Authors: | Tapas Makar, Vamshi K. Nimmagadda, Poornachander R. Guda, Brian Hampton, Weiliang Huang, Maureen A. Kane, Paul S. Fishman, Bernard Pessac, Christopher T. Bever, David Trisler |
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Format: | Article |
Language: | English |
Published: |
BMC
2018-05-01
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Series: | Stem Cell Research & Therapy |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s13287-018-0858-5 |
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