High mobility group box 1 (HMGB1): a pivotal regulator of hematopoietic malignancies

High mobility group box 1 (HMGB1): a pivotal regulator of hematopoietic malignancies

Abstract High mobility group box 1 (HMGB1) is a nonhistone chromatin-associated protein that has been widely reported to play a pivotal role in the pathogenesis of hematopoietic malignancies. As a representative damage-associated molecular pattern (DAMP), HMGB1 normally exists inside cells but can b...

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Bibliographic Details
Main Authors: Shunling Yuan, Zhaoping Liu, Zhenru Xu, Jing Liu, Ji Zhang
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Journal of Hematology & Oncology
Subjects:
High mobility group box 1 (HMGB1)
Hematopoietic stem cells (HSCs)
Bone marrow (BM) microenvironment
Inflammation
Chemoresistance
Online Access:http://link.springer.com/article/10.1186/s13045-020-00920-3

Internet

http://link.springer.com/article/10.1186/s13045-020-00920-3

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