Tonic 4-1BB Costimulation in Chimeric Antigen Receptors Impedes T Cell Survival and Is Vector-Dependent

Tonic 4-1BB Costimulation in Chimeric Antigen Receptors Impedes T Cell Survival and Is Vector-Dependent

Antigen-independent tonic signaling by chimeric antigen receptors (CARs) can increase differentiation and exhaustion of T cells, limiting their potency. Incorporating 4-1BB costimulation in CARs may enable T cells to resist this functional exhaustion; however, the potential ramifications of tonic 4-...

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Bibliographic Details
Main Authors: Diogo Gomes-Silva, Malini Mukherjee, Madhuwanti Srinivasan, Giedre Krenciute, Olga Dakhova, Yueting Zheng, Joaquim M.S. Cabral, Cliona M. Rooney, Jordan S. Orange, Malcolm K. Brenner, Maksim Mamonkin
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:Cell Reports
Subjects:
chimeric antigen receptor
costimulation
4-1BB
T cells
adoptive T cell therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717312767

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http://www.sciencedirect.com/science/article/pii/S2211124717312767

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