Differential pH Dynamics in Synaptic Vesicles From Intact Glutamatergic and GABAergic Synapses

Differential pH Dynamics in Synaptic Vesicles From Intact Glutamatergic and GABAergic Synapses

Synaptic transmission requires the presynaptic release of neurotransmitter from synaptic vesicles (SVs) onto the postsynaptic neuron. Vesicular neurotransmitter transporter proteins, which use a V-ATPase-generated proton gradient, play a crucial role in packaging neurotransmitter into SVs. Recent wo...

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Bibliographic Details
Main Authors: Melissa A. Herman, Thorsten Trimbuch, Christian Rosenmund
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Synaptic Neuroscience
Subjects:
vesicular transporter
proton gradient
VGLUT
VGAT
synaptic vesicle
Online Access:https://www.frontiersin.org/article/10.3389/fnsyn.2018.00044/full

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https://www.frontiersin.org/article/10.3389/fnsyn.2018.00044/full

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