Diketopiperazine-Based, Flexible Tadalafil Analogues: Synthesis, Crystal Structures and Biological Activity Profile

Diketopiperazine-Based, Flexible Tadalafil Analogues: Synthesis, Crystal Structures and Biological Activity Profile

Phosphodiesterase 5 (PDE5) is one of the most extensively studied phosphodiesterases that is highly specific for cyclic-GMP hydrolysis. PDE5 became a target for drug development based on its efficacy for treatment of erectile dysfunction. In the present study, we synthesized four novel analogues of...

Full description

Bibliographic Details
Main Authors: Adam Mieczkowski, Elżbieta Speina, Damian Trzybiński, Maria Winiewska-Szajewska, Patrycja Wińska, Ewelina M. Borsuk, Małgorzata Podsiadła-Białoskórska, Tomasz Przygodzki, Krzysztof Drabikowski, Lidia Stanczyk, Igor Zhukov, Cezary Watala, Krzysztof Woźniak
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Molecules
Subjects:
short peptide
diketopiperazine
tadalafil
PDE5 inhibitor
cytotoxicity
Online Access:https://www.mdpi.com/1420-3049/26/4/794

Internet

https://www.mdpi.com/1420-3049/26/4/794

Similar Items