Disinhibition of Cathepsin C Caused by Cystatin F Deficiency Aggravates the Demyelination in a Cuprizone Model

Disinhibition of Cathepsin C Caused by Cystatin F Deficiency Aggravates the Demyelination in a Cuprizone Model

Although the precise mechanism underlying initial lesion development in multiple sclerosis (MS) remains unclear, CNS inflammation has long been associated with demyelination, and axonal degeneration. The activation of microglia/macrophages, which serve as innate immune cells in the CNS, is the first...

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Bibliographic Details
Main Authors: Junjie Liang, Ning Li, Yanli Zhang, Changyi Hou, Xiaohan Yang, Takahiro Shimizu, Xiaoyu Wang, Kazuhiro Ikenaka, Kai Fan, Jianmei Ma
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-12-01
Series:Frontiers in Molecular Neuroscience
Subjects:
cystatin F
cathepsin C
microglia
CXCl2
demyelination
cuprizone
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2016.00152/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2016.00152/full

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