HOMER3 facilitates growth factor-mediated β-Catenin tyrosine phosphorylation and activation to promote metastasis in triple negative breast cancer

HOMER3 facilitates growth factor-mediated β-Catenin tyrosine phosphorylation and activation to promote metastasis in triple negative breast cancer

Abstract Background HOMER family scaffolding proteins (HOMER1-3) play critical roles in the development and progression of human disease by regulating the assembly of signal transduction complexes in response to extrinsic stimuli. However, the role of HOMER protein in breast cancer remains unclear....

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Bibliographic Details
Main Authors: Qinghua Liu, Lixin He, Siqi Li, Fengyan Li, Guangzheng Deng, Xinjian Huang, Muwen Yang, Yunyun Xiao, Xiangfu Chen, Ying Ouyang, Jinxin Chen, Xuxia Wu, Xi Wang, Libing Song, Chuyong Lin
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Journal of Hematology & Oncology
Subjects:
HOMER3
β-catenin
Tyrosine phosphorylation
Metastasis
TNBC
Online Access:https://doi.org/10.1186/s13045-020-01021-x

Internet

https://doi.org/10.1186/s13045-020-01021-x

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