Protein interaction and functional data indicate MTHFD2 involvement in RNA processing and translation

Protein interaction and functional data indicate MTHFD2 involvement in RNA processing and translation

Abstract Background The folate-coupled metabolic enzyme MTHFD2 is overexpressed in many tumor types and required for cancer cell proliferation, and is therefore of interest as a potential cancer therapeutic target. However, recent evidence suggests that MTHFD2 has a non-enzymatic function which may...

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Bibliographic Details
Main Authors: Costas Koufaris, Roland Nilsson
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Cancer & Metabolism
Subjects:
Interactome
Moonlighting
Heat shock proteins
RNA
Non-metabolic
Online Access:http://link.springer.com/article/10.1186/s40170-018-0185-4

Internet

http://link.springer.com/article/10.1186/s40170-018-0185-4

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