Protein interaction and functional data indicate MTHFD2 involvement in RNA processing and translation
Abstract Background The folate-coupled metabolic enzyme MTHFD2 is overexpressed in many tumor types and required for cancer cell proliferation, and is therefore of interest as a potential cancer therapeutic target. However, recent evidence suggests that MTHFD2 has a non-enzymatic function which may...
Main Authors: | Costas Koufaris, Roland Nilsson |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2018-09-01
|
Series: | Cancer & Metabolism |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s40170-018-0185-4 |
Similar Items
-
RNA–protein interactions: disorder, moonlighting and junk contribute to eukaryotic complexity
by: Anna Balcerak, et al.
Published: (2019-06-01) -
Phosphorylation in the Charged Linker Modulates Interactions and Secretion of Hsp90β
by: Lorenz Weidenauer, et al.
Published: (2021-07-01) -
Moonlighting Proteins: The Case of the Hexokinases
by: Carolina Rodríguez-Saavedra, et al.
Published: (2021-06-01) -
Human Long Noncoding RNA Interactome: Detection, Characterization and Function
by: Marek Kazimierczyk, et al.
Published: (2020-02-01) -
Identification of host proteins differentially associated with HIV-1 RNA splice variants
by: Rachel Knoener, et al.
Published: (2021-02-01)